Apealea® (paclitaxel micellar)
Apealea® (paclitaxel micellar) is a non-Cremophor based formulation of paclitaxel. It received market authorization by the European Commission in November of 2018, making it Europe’s first non-Cremophor formulation of paclitaxel approved for use in ovarian cancer. Branded as Paclical® in certain countries, Apealea® was developed by Oasmia Pharmaceutical AB in Sweden utilizing their proprietary XR17 micelle platform technology. In its pivotal clinical study comparing to Taxol®, Apealea® preserved activity of paclitaxel with similar OS and PFS with a comparable safety and tolerability profile despite higher drug load. Pre-treatment, shorter infusion times, and reduction of Cremophor-associated side effects were also observed.